From ions to insulin
نویسنده
چکیده
Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.
منابع مشابه
بررسی اثر کاتیون‌های فلزی V5+, W6+ , Zn2+ بر میزان ترشح انسولین و فعالیت آنزیم گلوکوکیناز در جزایر لانگرهانس جدا شده از موش صحرایی سالم و دیابتی
Background: Insulin dependant Diabetes Mellitus (IDDM) is associated with a reduction in production or secretion of insulin from pancreatic Islets. On the other hand increase in insulin secretion will result in destruction of islets that will lead to Diabetes .Therefore the factors that could regulate secretion will prevent the onset of diabetes . Glucose metabolism that commences with the gluc...
متن کاملاثر عوامل گیاهی کاهنده قند خون بر آنزیم‌های آنتی‌اکسیدان و یونهای فلزی در موش‌های دیابتی شده با استرپتوزوتوسین
Background: up to know many herbal medicines with different oral formulations have been recommended for diabetes. The aim of this study was to investigate the effect of 4 herbal hypoglycemic agents include garlic (Allium sativum) neem (Azadirachta indica), tulsi (Ocimum sanctum) and bitter gourd (Momordica charantia) on blood glucose, antioxidant enzymes and metal ions in diabetics Methods: Cr...
متن کاملMONOPHASIC STATE OF INSULIN SECRETION IN ISOLATED RAT ISLETS OF LANGERHANS BY K+, Ca2+ AND GLUCOSE
Isolation of rat islets of Langerhans was carried out by using collagenase and the destruction of exocrine tissue was performed through the injection of Hanks' solution into the common bile duct. The identification of the islets was done by techniques including the use of a stereomicroscope against a black background. Vital staining was done by an injection of neutral red solution through t...
متن کاملRemoval of Cd(II) ions from contaminated water by a new modified magnetic chitosan nano composite
Magnetic chitosan nanocomposites are one of the more recent advanced groups of adsorbents used to remove contaminants from waste water. In this research, N- Nicotinyl-N', N"-bis (Hexamethylenyl) phosphoric triamide (HE) was used as an additive to form a new nanocomposite with the structure of chitosan / 5% Fe3O4 Nps/10% HE resulting in the highly efficient removal of Cd(II...
متن کاملZn(II) ions co-secreted with insulin suppress inherent amyloidogenic properties of monomeric insulin.
Insulin, a 51-residue peptide hormone, is an intrinsically amyloidogenic peptide, forming amyloid fibrils in vitro. In the secretory granules, insulin is densely packed together with Zn(II) into crystals of Zn(2)Insulin(6) hexamer, which assures osmotic stability of vesicles and prevents fibrillation of the peptide. However, after release from the pancreatic beta-cells, insulin dissociates into...
متن کاملHeavy metals removal from wastewater by using different kinds of magnetite nanoadsorbents: effects of different organic and inorganic coatings on the removal of copper and lead ions
Co-precipitation procedure was applied in order to obtain different kinds of magnetic nanoadsobents for the removal of Pb(II) and Cu(II) toxic metal ions from wastewater samples. Prepared nanoadsorbents were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometer (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The average sizes of t...
متن کامل